Hello, Mr. Jelínek,

I would like to ask if the exact mechanism of action of omega 3 on anticoagulants is known. I understand it in the case of vitamin K because Warfarin is actually an anti-vitamin K, but I haven't read about the omega 3 mechanism anywhere.

Thank you.

P.S. I highly commend the quality of your course.

Thank you for the compliment; I am glad that you are enjoying the course. You are presenting me with a teaching challenge in the form of the necessity to cater information not only to the general public, who are interested in delving into the secrets of proper nutrition, but also to you - the experts - whose know-how far exceeds the expert framework of this course. This drives me to avoid disappointment and further propels me forward...:-)

Anticoagulants such as Warfarin or Heparin only prevent the formation of blood clots (meaning they do not affect existing clots) by competing with vitamin K, which the body needs for the synthesis of coagulation factors. The mechanism of omega-3's influence on platelet aggregation is different: Omega-3 fatty acids compete with omega-6 (primarily arachidonic acid) for incorporation into the platelet membranes (this is one reason why it is recommended to ensure an omega-3 to omega-6 ratio of 1:1-5). If the primary components of the omega-3 intake spectrum are EPA and DHA, there is an increase in the production of prostaglandin I2 (prostacyclin - PGI2), which directly inhibits platelet aggregation and has local vasodilatory effects. Concurrently, there is a decrease in the production of thromboxane A2, a derivative of arachidonic acid produced by platelets, which enhances vasoconstriction and supports the activation of new platelets.

These effects result in prolonged bleeding time and reduced platelet aggregation, with the extent depending not only on the omega-3 to omega-6 ratio but also on the medications used (medications containing acetylsalicylates also play a role). Achieving this state through dietary adjustments is very challenging, and such situations are primarily associated with the use of higher doses of omega-3 from supplements.

Themes:  Omega-3   Anticoagulant therapy