Hello,
I know we have covered fructose and its effects on the liver, but could you please explain once more what happens in the liver after consuming fructose? And I've heard that glucose-fructose syrup is even worse.
Thank you.
Excessive fructose intake is associated with the overgrowth of certain gut bacteria and subsequently increased intestinal permeability. Bacteria contain endotoxins, which promote increased production of inflammatory substances (cytokines) in some liver cells. Simultaneously, during fructose metabolism in the liver, substances are formed (glyceraldehyde-3-phosphate, dihydroxyacetone phosphate, pyruvate) that are transported into mitochondria at high concentrations, leading to the stimulation of a process called de novo lipogenesis (excess carbohydrates are converted into fat because this metabolic state prevents fatty acids from entering the mitochondria). The resulting fat particles are then deposited in the liver and support the development of steatosis. High-fructose corn syrup is a source of fructose, and it should be avoided just like all other "artificial" sources of this sugar.
Questions answered by
Mgr. Martin Jelinek
Lecturer and author of the educational system
Nutrition educator, lecturer, and author of the educational system and the ZOF learning application.
Mgr. Martin Jelínek has been systematically involved in nutrition education since 1999. He is the founder of ATAC, the educational company behind NutriCourses, and the author of an educational system focused on nutrition, healthy lifestyle, and the practical application of nutrition knowledge.
He graduated from the Faculty of Science at Masaryk University in Brno. Throughout his professional career, he has combined nutrition, education, and the practical application of acquired knowledge. His educational system also includes the ZOF (Zone of Optimal Functioning) learning application, where students turn theory into practical work with meal plans.
In 2007, he launched the first intake of a six-month course focused on the education of nutrition advisors. Over time, this course became the foundation for the further development of the educational system and a range of specialised courses.